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Purpose: The purpose of this study is to identify the moderating and mediating effects of resilience in the relationship between symptom experience and quality of life. Methods: Participants were recruited from one general hospital and one hospital specialized in hemodialysis located in Busan city. The participants included 105 patients diagnosed with chronic renal failure who had been receiving hemodialysis twice a week or more on a regular basis. Data collection was conducted from December 14, 2017, to January 15, 2018. Collected data were analyzed using the SPSS/WIN 24.0 program. Results: There were significant correlations between participants' symptom experience and resilience (r=-.36, p<.001), symptom experience and quality of life (r=-.50, p<.001), and resilience and quality of life (r=.67, p<.001), respectively. Resilience had a partial mediating effect (z=-3.48, p<.001) in the relationship between symptom experience and quality of life but did not have moderating effects. Conclusion: To improve the quality of life among patients on hemodialysis, it is necessary to develop interventions that enhanceresilience in addition to providing symptom relief.