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Background: Licorice is an important medicinal plant, but climate conditions can hinder seed production. Because it is difficult to produce the seeds, Korea mostly depends on the imported product. In addition, when grown domestically, the standard ingredients do not comply with those of the Korean Pharmacopoeia (glycyrrhizin 2.5% and liquritigenin 0.7%). Therefore, it is necessary to develop licorice variety suitable for the domestic environment. Methods and Results: A new interspecific hybrid cultivar designated ‘Dagam’, was developed from Glycyrrhiza glabra × G. uralensis (G. korshinskyi Grig.) and is regarded as a high-yielding and high-quality licorice by Rural Development Administration. On average the yield for ‘Dagam’ was recorded 431.5 ㎏/10a. The cultivar displayed strong brown spot disease and lodging resistance. Additionally, the glycyrrhizin and liquiritigenin contents of ‘Dagam’ (3.0 and 0.7%, respectively) met, the Korean Pharmacopoeia standard. This cultivar can widely adapt to most cultivation areas in Korea except Jejudo, Gangwondo, and the mountain-alpine regions. Furthermore, ‘Dagam’ was not showed any cytotoxicity and high cell viability compared to ‘G. uralensis’. Conclusions: The interspecific hybrid cultivar ‘Dagam’ will contribute to the stability of domestic cultivation of licorice in Korea.