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In these days, the dental market is facing a very difficult management situation for small and medium-sized dental clinics due to overheated competition. Government tries to expand and promote the coverage of non-benefit care and preventive care. In this preventive care area, periodontal disease is ranked as a high frequent disease. Dental clinics will have to come up with a new management strategy to suit this situation. This study therefore conducts analysis of the operational feasibility and strategic plan of the dental prevention center. We use an economic evaluation analysis for three dental clinics currently operating dental prevention centers. First, we itemize benefit and cost field by reviewing literatures and clinic’s second data; Benefit consists of medical profit and others; Cost consists of 1) Labor cost (dentist, dental hygienist, others), 2) Material cost (material medica, medical devices, others), and 3) Maintenance cost. Next, we perform an economic evaluation analysis based on estimated benefit and cost values. There are lots of economic evaluation indicators, but this study selects benefit and cost, net present value, and internal rate of return. The results of the three dental clinics’ dental prevention centers’ B/C, NPV, and IRR all exceed the standard values, indicating economic feasibility; (B/C≧1, NPV≧0, IRR≧R). In detail, A dental clinic’s result shows that B/C=3.07, NPV=1,988,233,000, IRR=95.0%; B dental clinic’s result shows that B/C=2.90, NPV=1,589,604,000, IRR=88.4%; C dental clinic’s result shows that B/C=3.15, NPV=1,494,247,000, IRR=96.4%. Also, IRR value has an more effect to small clinic than bigger one. The Dental Prevention Center could be suggested as a strategic plan to provide a competitive advantage to the dental clinics that struggling as well as the dental clinics newly entering the market in the future.