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Purpose: The purpose of this study was to devise an accurate machine learning model for predicting silica concentrations following the addition of impurities, through time series analysis of mining data. Methods: The mining data were preprocessed and subjected to time series analysis using the machine learning model. Through correlation analysis, valid variables were selected and meaningless variables were excluded. To reflect changes over time, dependent variables at baseline were treated as independent variables at later time points. The relationship between independent variables and the dependent variable after n point was subjected to Pearson correlation analysis. Results: The correlation (R2) was strongest after 3 hours, which was adopted as a dependent variable. According to root mean square error (RMSE) data, the proposed method was superior to the other machine learning methods. The XGboost algorithm showed the best predictive performance. Conclusion: This study is important given the current lack of machine learning studies pertaining to the domestic mining industry. In addition, using time series analysis in mining data will show further improvement. Before establishing a predictive model for the proposed method, predictions should be made using data with time series characteristics. After doing this work, it should also improve prediction accuracy in other domains.