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Background: Robotic-assisted radical prostatectomy (RARP) using da VinciⓇ Surgical System is an emerging technique for management of prostate cancer. With retrospective chart review of patients who had RARP or radical retropubic prostatectomy (RRP), we tried to evaluate and compare the effects on the factors related to patients’ outcomes. Methods: We reviewed the data of 144 patients who underwent RARP (group R, n = 76) or RRP (group C, n = 68) under general anesthesia in the same time period retrospectively. The age, anesthesia time, transfusion rate, PACU time, administration of additional analgesics at PACU, admission day after the operation, postoperative complications and intraoperative PaCO2 were examined and compared. Results: Group R showed significantly lower transfusion rate and more rapid discharge after the operation. Intraoperative PaCO2 was increased in process of time in group R. Other variables were not significantly different between the two groups. In group R, mild neuropathy occurred in 2 patients and subcutaneous emphysema occurred in 1 patient. Conclusion: Patients who had RARP needed significantly less transfusion during operation and significantly shorter admission time compared to patients who had RRP.