these study, novel 1,4-disubstituted carbocyclic nucleoside analogues were synthesized as potential antiviralagents. The coupling reaction of the alcohol 8α with natural bases using Mitsunobu reaction afforded the target ...

Recently, it was found that the formation of reactive metabolites by cytochrome P450s as well as the depletion of glutathione would play important roles in hepatotoxicity induced by 1-bromopropane. In the present study, ...

Parkinson’s disease (PD), one of common neurodegenerative diseases, is caused by the death of dopaminergic neurons in the substantia nigra pars compacta. The loss of dopaminergic neurons in PD is associated with oxidative ...

CCL2 overexpression is associated with macrophage recruitment during immune response and poor patientprognosis in various cancers, such as prostate, breast, pancreatic, and liver cancer. For developing CCL2 inhibitors, ...

Andrographolide, a diterpenoid lactone of theplant Andrographis paniculata, has been shown to becytotoxic against various cancer cells in vitro. In thepresent study, a series of b-amino-c-butyrolactone analogueshas been ...

A new unsaturated hydroxy fatty acid was isolated from the leaves of Cucurbita moschata through repeated silica gel column chromatography and chemical methods. The structure of the new fatty acid was determined as ...

In order to investigate the preliminary repeat oral dose toxicity and to determine the highest dosage for further 4-week repeated dose toxicity test, Low Molecular Weight Fucoidan (LMF) has been showed various pharmacological ...

Adipocyte differentiation in human bone marrow mesenchymal stem cells (hBM-MSCs) is not as efficient as that in murine pre-adipocytes when induced by adipogenic agents including insulin, dexamethasone,and 3-isobutyl-1-me ...

A polymorphic fungus, Candida albicansand vaginitis. Recent reports indicate that the fungus is a main etiological agent for the arthritis. In search of new sourcesfor treatment of the fungal arthritis, we examined ...