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The photocatalytic removal of amoxicillin (AMX) over a TiO2/Ge composite under ultraviolet-Airradiation was investigated in this study. The optimal composition of the TiO2/Ge composite wasdetermined by the response surface method to maximize AMX removal and the reduction of toxicity inthe aqueous phase; the photocatalytic degradation of AMX over the optimal TiO2/Ge composite wasapproximately 91.6%.