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The purpose of this study was to investigate the changes of IL-6(interleukin-6) and HOMA -IR in middle aged women after 12weeks of combined exercise. Subjects were consisted of sixteen middle aged abdominal visceral obese women(Control ; 8, Exercise ; 8). The combined training program included aerobic exercise and resistance exercise. Aerobic exercise composed of 30 minutes a at 60~75% of HRR.(heart rate reserve) Resistance exercise composed of 40 minutes a day at 70% of 1RM(repetition maximum). The program was conducted 4 times a week for 12 weeks. We found that the combined exercise significantly decreased percent body fat, body fat, total abdomianl fat volume and visceral fat volume and significantly increased LBM(lean body mass). In addition, IL-6 concentration was significantly decreased and the change of IL-6 was significantly positive correlated with the change of HOMA-IR and visceral fat volmue respectively after 12 weeks in combined exercise. Therefore, So it is maybe thought that 12weeks combined exercise improved IL-6 and HOMA-IR for cardiovascular disease and diabetes treatment.


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IL-6, adipokine, visceral fat, HOMA-IR