22q11.2 deletion syndrome (22q11.2DS) is a disorder caused by microdeletions in the long arm of chromosome 22. It is one of the most common chromosomal micro-deletion disorders. Clinical symptoms are caused by heterozygous ...

BackgroundAllogeneic hematopoietic stem cell transplantation (HSCT) is the preferred curative ther-apy for children with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leu-kemia (ALL). We evaluated the treatment ...

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder characterized by het-erogenous lesions infiltrated with CD1a+/CD207+ cells. Although LCH has a relatively good prognosis, the prognosis for patients with ...

Hepatoblastoma is the most common malignant hepatic tumor in infants and young children and accounts for approximately 1% of all pediatric malignancies. A treatment strategy incorporating chemotherapy and surgical resection ...

Langerhans cell histiocytosis (LCH) is the most common histiocytic disorder caused by the clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in the lesion. Advances in genomic sequencing ...

Juvenile xanthogranuloma (JXG) is a rare histiocytic disorder primarily affecting children, typically presenting as self-limiting skin lesions. However, extracutaneous JXG (extra-JXG) or systemic JXG (sJXG) can involve ...