12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) is an enzymatic product of prostaglandin H2(PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. Despite the high level of 12-HHT present in ...

15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a natural ligand that activates the peroxisome proliferators- activated receptor (PPAR) γ, a member of nuclear receptor family im plicated in regulation of lipid metabolism and adipocyte ...

2-deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. ...

2′-Hydroxycinnamaldehyde (HCA), the active component isolated from the stem bark of Cinnamomum cassia , exerts anticancer effects through multiple mechanisms. We recently determined that HCA inhibits signal transducer and ...

The three-dimensional (3D) genome architecture is fundamental to orchestrating gene expression, safeguarding genome integrity and establishing cell-type-specific transcriptional landscapes. In cancer, this spatial genome ...

Since its initial description 35 years ago as an inducible molecule expressed in cytotoxic and helper T cells, 4-1BB has emerged as a crucial receptor in T-cell-mediated immune functions. Numerous studies have demonstrated ...

The chromatin architecture of mammalian genomes is intricately organized into a multilayered three-dimensional structure that features compartments, topologically associating domains (TADs), and chromatin loops1,2. Individual ...

A variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), ...

Our previous report has demonstrated that 5-formylhonokiol (FH), a derivative of honokiol (HK), exerts more potent anti-proliferative activities than honokiol in several tumor cell lines. In present study, we first explored ...

Angiogenesis should be precisely regulated because disordered neovascularization is involved in the aggravation ofmultiple diseases. The vascular endothelial growth factor (VEGF)-A/VEGF receptor 2 (VEGFR-2) axis is crucial ...