Non-small cell lung cancer remains a major clinical challenge due to aggressive metastasis and limited therapeutic modalities. The innate cytotoxicity of natural killer (NK) cells and their ability to eliminate malignant ...

Conventional tumor-targeted therapies primarily focus on drug delivery systems exploiting the tumor microenvironment for controlled drug release. While prodrug strategies activate small-molecule drugs in tumors, they rely ...

Inflammatory bowel disease (IBD) remains a therapeutic challenge due to its ongoing inflammation and the limited availability of effective local therapies. This study developed a biomimetic nanocomposite, layered double ...

Current prodrug strategies in clinical practice still face several challenges, such as insufficient targeting specificity, substantial systemic toxicity, and complex administration protocols, which urgently need to be ...

Substantial progress has been made in developing artificial small-diameter vascular grafts (SDVGs), yet the contribution of perivascular adipose tissue (PVAT) to vascular graft healing remains poorly understood. This study ...

The immune checkpoint lymphocyte activation gene-3 (LAG-3) interacts with major histocompatibility complex class II and fibrinogen-like protein 1 (FGL-1) to suppress T cell activity, contributing to resistance against ...

Mesothelin (MSLN) is up-regulated in many tumors, including pancreatic tumors, making it a promising therapeutic target. We used a phage-displayed peptide library to identify an MSLN-binding peptide. CTILWSLTC, synthesized ...

Parkinson’s disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, accompanied by oxidative stress and neuroinflammation. While nervonic acid (NA) ...

Triple-negative breast cancer (TNBC) remains a highly aggressive subtype with limited treatment options and poor prognosis. While most therapies target tumor cells, the tumor microenvironment (TME), particularly cancer-associated ...

Hydrogel-based tissue adhesives hold promise for diverse biomedical applications, yet achieving strong, durable adhesion to wet, dynamic biological surfaces remains challenging. The catechol-containing amino acid ...